Generalizability to the US population: Based on National Health and Nutrition Examination Survey (NHANES) data from 2007 to 2012, it appears that 7.6% or 16.8 million US adults, and 16.7% or 8.2 million of those with treated hypertension, would meet the SPRINT eligibility criteria. Among patients without CKD: ≥30% decline in GFR to Among patients with chronic kidney disease: composite renal endpoint (decrease in GFR ≥50%, need for HD, renal transplant) 1.1% vs.routine BP control, absolute event rates: Important secondary endpoints for intensive vs. routine management, absolute event rates): Individual components (event rates for intensive vs. The primary outcome, myocardial infarction (MI), acute coronary syndrome (ACS), stroke, congestive heart failure (CHF), or cardiovascular (CV) death, was significantly lowered in the intensive BP management arm compared with the routine management arm (5.2% vs. The trial was terminated early due to overwhelming evidence of benefit.
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A medical condition likely to limit survival to Symptomatic heart failure within the past 6 months or left ventricular ejection fraction Cardiovascular event or procedure or hospitalization for unstable angina within last 3 months.eGFR Glomerulonephritis treated with or likely to be treated with immunosuppressive therapy.Arm circumference too large or small to allow accurate BP measurement with available devices.
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